Indications
Therapeutic Class
Pharmacology
Dosage & Administration
Depression:
- Adult: Low dose initially increased as necessary to 75-100 mg daily in divided doses or as a single dose (max. 150 mg daily)
- Adolescent & Elderly: 30-50 mg daily in divided doses; Child not recommended for depression
Nocturnal enuresis:
- Child 7 years: 10 mg
- 8-11 years: 10-20 mg
- Over 11 years: 25-35 mg, 30 minutes before bedtime; max period of treatment (including gradual withdrawal) 3 months- full physical examination and ECG before further course.
Interaction
Contraindications
Side Effects
Pregnancy & Lactation
Precautions & Warnings
Overdose Effects
Symptoms: Severe hypotension, cardiac dysrhythmias, shock, CHF, pulmonary oedema, convulsions, and CNS depression, including coma; changes in ECG.
Management: Symptomatic and supportive treatment. Admin IV Na bicarbonate, benzodiazepines. Admin activated charcoal to reduce absorption. Emesis is contraindicated. Initiate cardiac monitoring and observe for signs of CNS or resp depression, hypotension, cardiac dysrhythmias and/or conduction blocks, and seizures.
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